Take care of the babies by giving them what they need when they feel hungry, thirsty or sleepy. The game allows you to control the girl's satisfaction in many levels (like health, hygiene, boredom), you have to ensure that no one of these is too low. And you'll have higher levels of satisfaction to reach as you progress in the game.
Click on the place where you find what the baby needs. Then click on the baby to see his status in various areas (health, hygiene, boredom); you have to ensure that none of these goes too low. If you need clothes or books, click at 'shop - item' and then click at the clothing or book you want. To pay you'll have to use the money you earn when you complete the successive levels.